Elizabeth (Abby) Stahl

Company: Innovative Genomics Institute

Job title: Postdoctoral Fellow

Seminars:

Genome Editing in the Central Nervous System With Engineered Cas9-RNPs 3:45 pm

Cas9 ribonucleoproteins (RNPs) fused to cationic peptides enables local genome editing in the mouse brain, comparable to delivery with adeno-associated virus 9 (AAV9) Treatment with Cas9-RNPs resulted in lower levels of vehicle-specific antibodies and T-cell activation compared to Cas9-AAV9, however, Cas9-RNPs lead to microglial activation that was mitigated by reducing endotoxins/LPS during protein production Additional…Read more

day: Day 1 PM