Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient & Specific Genome Engineering For Cell Therapy Development

Time: 3:30 pm
day: Day One


• Explore the discovery of new CRISPR enzymes from metagenomic data, both type II and type V systems and discuss & compare systems
• Investigate high-level editing in primary T cells at the alpha-chain of the TCR locus (key locus for allogenic CAR T development)
• Simultaneous inactivation of the beta-chain TCR locus enables TCRbased T cell therapeutics dev
• Investigate the translatability of both internal and CMO-based protein manufacturing established